Guest lecture by Ralph Stadhouders | Type-2 immunopathologies: closing in on lymphocytes associated with severe, therapy-resistant disease

Guest lecture by Ralph Stadhouders PhD (Dept Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands)

Title: Type-2 immunopathologies: closing in on lymphocytes associated with severe, therapy-resistant disease

Host: Monika Wolkers

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Abstract
The mainstay treatment for type-2 immunopathologies such as asthma are corticosteroids. Unfortunately, still ~10% of patients present with a form of corticosteroid-resistant disease - for reasons that remain poorly understood. In this seminar, I will highlight our recent progress aimed at identifying and characterizing the immune cells subsets responsible for severe therapy-resistant type-2 inflammatory disease of the airways. These include the characterization of a new subset of steroid-resistant innate lymphoid cells (1), linking atypical cytotoxic T cell populations to severe asthma (2) and discovering epigenomic mechanisms controlling memory T cell recall that may be altered in severe asthmatics (3).