Guest lecture by Marvin van Luijn | Lymphocytes going off road in multiple sclerosis: from hitmen to targets
Medical priority Immunity & inflammation EventPlesmanlaan 125
1066 CX Amsterdam
The Netherlands
On 1 April 2025 Marvin van Luijn PhD (Dept Immunology, ErasmusMC, Rotterdam, The Netherlands) will give a guest lecture at Sanquin Amsterdam
Title: Lymphocytes going off road in multiple sclerosis: from hitmen to targets
Host: Anja ten Brinke
Abstract
The research group of Marvin van Luijn aims to identify the triggers, receptors and effector programs of lymphocytes that infiltrate the brain of people with multiple sclerosis (MS). With genetic predisposition and infection with Epstein-Barr virus (EBV) as the underlying factors, they elaborate on changes in B- and T-cell interaction both inside and outside the brain as key pathogenic events. To do so, they use state-of-the art technologies including B and T cell subset-focused scRNA-seq and spectral cytometry as well as different human in vitro models to mimic critical processes that shape B and T cells along their way into the brain. In this endeavor, they stratify our patient cohorts covering the whole lifespan of MS (MS center ErasMS) based on clinical course, treatment effects and both genetic risk scores and anti-EBV responses to assess the specificity of these events for MS.
