Adalimumab

• Development of antidrug antibodies against adalimumab maps to variation within the HLA-DR peptide-binding groove. Tsakok T et al., JCI Insight. 2023 Feb 22;8(4):e156643. doi: 10.1172/jci.insight.156643. PMID: 36810251.

 

• Drug-tolerant detection of anti-drug antibodies in an antigen-binding assay using europium chelate fluorescence. van Strien et al., J Immunol Methods. 2023 Mar;514:113436. doi: 10.1016/j.jim.2023.113436. Epub 2023 Jan 28. PMID: 36716916.

 

• Dried blood spots from finger prick facilitate therapeutic drug monitoring of adalimumab and anti-adalimumab in patients with inflammatory diseases. Kneepkens et al., Br J Clin Pharmacol. 2017 Aug 9.

 

• Long-term treatment response in rheumatoid arthritis patients starting adalimumab or etanercept with or without concomitant methotrexate. l'Ami et al., Clin Exp Rheumatol. 2017 May-Jun;35(3):431-437:

 

• Comparing a tapering strategy to the standard dosing regimen of TNF inhibitors in rheumatoid arthritis patients with low disease activity. Plasencia et al., Clin Exp Rheumatol. 2016 Jul-Aug;34(4):655-62. Epub 2016 May 19. 

 

• Search for a concentration-effect curve of adalimumab in ankylosing spondylitis patients. Marsman A et al., Scand J Rheumatol. 2016 Jul;45(4):331-4

 

• Using monoclonal antibodies as an international standard for the measurement of anti-adalimumab antibodies.  van Schouwenburg et al., J Pharm Biomed Anal. 2016 Feb 20;120:198-201.

 

• Systematic comparison of drug-tolerant assays for anti-drug antibodies in a cohort of adalimumab-treated rheumatoid arthritis patients. Bloem et al., J Immunol Methods 2015; 418:29-38

 

• Adalimumab trough concentrations in patients with rheumatoid arthritis and psoriatic arthritis treated with concomitant disease-modifying antirheumatic drugs. Vogelzang et al., Ann Rheum Dis 2015; 74(2):474-5.

 

• Key findings towards optimising adalimumab treatment: the concentration-effect curve. Pouw et al., Ann Rheum Dis 2013 Dec 10.

 

• Functional analysis of the anti-adalimumab response using patient-derived monoclonal antibodies. van Schouwenburg et al., J Biol Chem 2014; 289(50):34482-8.