Ilse (I.) Timmerman PhD

Training

Oncology & Vascular Cell Biology 

Thesis

2013, University of Amsterdam, The Netherlands
'Dynamic control of VE-cadherin-based junctions'
 

Research interests

Cell-cell adhesion within the context of vascular tissue has been my major scientific interest in the past years. I identified several signaling cascades that target the central component of endothelial cell-cell adhesions, VE-cadherin, and thereby control vascular integrity, angiogenesis and leukocyte extravasation. To shift my focus to more translational research I decided to broaden my scientific scope to cell-cell adhesion in relation to cancer, particularly on interactions within the bone marrow microenvironment, comprising endothelial cells and mesenchymal stromal cells (MSC). I’m currently studying the cross-talk between MSC and tumor cells in bone marrow of patients with neuroblastoma. 

Technology

• In vitro adhesion, migration and angiogenesis assays
• In vivo vascular permeability assays
• Colony-Forming Unit assays
• Flow cytometry, immunoprecipitation, western blotting, antibody production and purification
• Confocal microscopy and live cell imaging

Resume

2015-present	Postdoctoral Researcher,  Dept of Hematopoiesis, Lab for Stem Cell Research, Sanquin. Topic: Bone marrow microenvironment in neuroblastoma patients
2013-2015	Postdoctoral researcher, Dept of Vascular Cell Biology, Vestweber-lab, Max Planck Institute for Molecular Biomedicine Muenster, Germany. Research topic: Regulation of vascular integrity in vivo
2008-2013	PhD student, Dept of Molecular Cell Biology, Sanquin. Research topic: Control of vascular permeability, leukocyte extravasation and angiogenesis by Vascular Endothelial (VE)-Cadherin.
2006-2008	Master of Science in Oncology, VU University, Amsterdam, The Netherlands