Natasja (N.A.M.) Kragten
Training
- Hogeschool van Utrecht, HLO, specialisatie Moleculaire Biologie
- Universiteit Utrecht, Medische Biologie; Specialisatie Immunity & Infection
Research interests
Immunology, Tumor Biology, CAR- T cells
Technology
CRISPR, Transduction, Transfection, Western Blotting, RNA isolation, Real-Time PCR, FACS, In vivo and In vitro assays
Resume
- 2008-2011 Research Technician at the AMC; Department of Experimental Immunology
- 2011- 2014 Research Technician Sanquin Research, Department of Hematopoiesis, Adaptive Immunity lab
- 2015- June 2023 Senior Technician Sanquin Research, Department of Hematopoeisis, van Gisbergen lab
- July 2023- recent Senior Technician Sanquin Research, Department of Hematopoeisis, Foskolou lab
Selected papers
First Author publications:
Hobit and Blimp-1 instruct the differentiation of iNKT cells into resident-phenotype lymphocytes after lineage commitment. Kragten NA, Taggenbrock RL, Parga Vidal L, van Lier RA, Stark R, van Gisbergen KP. Eur J Immunol. 2022 Mar;52(3):389-403. doi: 10.1002/eji.202149360. Epub 2022 Jan 9.PMID: 34897659
Blimp-1 induces and Hobit maintains the cytotoxic mediator granzyme B in CD8 T cells. Kragten NAM, Behr FM, Vieira Braga FA, Remmerswaal EBM, Wesselink TH, Oja AE, Hombrink P, Kallies A, van Lier RAW, Stark R, van Gisbergen KPJM.Eur J Immunol. 2018 Oct;48(10):1644-1662. doi: 10.1002/eji.201847771. Epub 2018 Aug 16.PMID: 30051906
Other publications:
Memory CD8+ T cells upregulate glycolysis and effector functions under limiting oxygen conditions. Beumer-Chuwonpad A, van Alphen FPJ, Kragten NAM, Freen-van Heeren JJ, Rodriguez Gomez M, Verhoeven AJ, van den Biggelaar M, van Gisbergen KPJM. Eur J Immunol. 2023 Feb;53(2):e2249918. doi: 10.1002/eji.202249918. Epub 2022 Dec 8.PMID: 36482267
Hobit and Blimp-1 regulate TRM abundance after LCMV infection by suppressing tissue exit pathways of TRM precursors. Parga-Vidal L, Taggenbrock RLRE, Beumer-Chuwonpad A, Aglmous H, Kragten NAM, Behr FM, Bovens AA, van Lier RAW, Stark R, van Gisbergen KPJM.Eur J Immunol. 2022 Jul;52(7):1095-1111. doi: 10.1002/eji.202149665. Epub 2022 Apr 15.PMID: 35389518
Effector differentiation downstream of lineage commitment in ILC1s is driven by Hobit across tissues. Friedrich C, Taggenbrock RLRE, Doucet-Ladevèze R, Golda G, Moenius R, Arampatzi P, Kragten NAM, Kreymborg K, Gomez de Agüero M, Kastenmüller W, Saliba AE, Grün D, van Gisbergen KPJM, Gasteiger G.Nat Immunol. 2021 Oct;22(10):1256-1267. doi: 10.1038/s41590-021-01013-0. Epub 2021 Aug 30.PMID: 34462601
Hobit identifies tissue-resident memory T cell precursors that are regulated by Eomes. Parga-Vidal L, Behr FM, Kragten NAM, Nota B, Wesselink TH, Kavazović I, Covill LE, Schuller MBP, Bryceson YT, Wensveen FM, van Lier RAW, van Dam TJP, Stark R, van Gisbergen KPJM.Sci Immunol. 2021 Aug 20;6(62):eabg3533. doi: 10.1126/sciimmunol.abg3533.PMID: 34417257
Murine iNKT cells are depleted by liver damage via activation of P2RX7. Bovens AA, Wesselink TH, Behr FM, Kragten NAM, van Lier RAW, van Gisbergen KPJM, Stark R.Eur J Immunol. 2020 Oct;50(10):1515-1524. doi: 10.1002/eji.201948509. Epub 2020 May 27.PMID: 32390174
Tissue-resident memory CD8+ T cells shape local and systemic secondary T cell responses. Behr FM, Parga-Vidal L, Kragten NAM, van Dam TJP, Wesselink TH, Sheridan BS, Arens R, van Lier RAW, Stark R, van Gisbergen KPJM.Nat Immunol. 2020 Sep;21(9):1070-1081. doi: 10.1038/s41590-020-0723-4. Epub 2020 Jul 13.PMID: 32661361
T RM maintenance is regulated by tissue damage via P2RX7. Stark R, Wesselink TH, Behr FM, Kragten NAM, Arens R, Koch-Nolte F, van Gisbergen KPJM, van Lier RAW.Sci Immunol. 2018 Dec 14;3(30):eaau1022. doi: 10.1126/sciimmunol.aau1022.PMID: 30552101
Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes. Mackay LK, Minnich M, Kragten NA, Liao Y, Nota B, Seillet C, Zaid A, Man K, Preston S, Freestone D, Braun A, Wynne-Jones E, Behr FM, Stark R, Pellicci DG, Godfrey DI, Belz GT, Pellegrini M, Gebhardt T, Busslinger M, Shi W, Carbone FR, van Lier RA, Kallies A, van Gisbergen KP.Science. 2016 Apr 22;352(6284):459-63. doi: 10.1126/science.aad2035.PMID: 27102484
Other activities
MLII Labcoordinator
