Content
ADAMTS13 and thrombotic thrombocytopenic purpura: On the edge between hemostasis and autoimmunityDownload thesis (University repository)
Chapter 1
General Introduction
Chapter 2
Dissecting the pathophysiology of immune thrombotic thrombocytopenic purpura: interplay between genes and environmental triggers abstract
Chapter 3
Conformational plasticity of ADAMTS13 in immune TTP; a blood-based remake of Dr. Jekyll and Mr. Hyde
Chapter 4
Rational modulator design by exploitation of protein–protein complex structures abstract
Chapter 5
Mass spectrometry-assisted identification of ADAMTS13-derived peptides presented on HLA-DR and HLA-DQ abstract
Chapter 6
N-glycan mediated shielding of ADAMTS13 prevents binding of pathogenic autoantibodies in immune-mediated TTP
Chapter 7
Structure-based design of cyclic glycoprotein Iba-derived peptides affecting platelet interaction with von Willebrand factor under shear conditions
Chapter 8
General Discussion
