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Viribus Unitis - the molecular synergism between coagulation factors VIII and IX

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Chapter 1 

General introduction

Chapter 2

Unique surface-exposed hydrophobic residues in the C1 domain of factor VIII contribute to cofactor function and von Willebrand factor binding abstract

Chapter 3

Hydrogen-deuterium exchange mass spectrometry identifies activated factor IX-induced molecular changes in activated factor VIII abstract

Chapter 4

Factor VIII-driven changes in activated factor IX explored by hydrogen-deuterium exchange mass spectrometry abstract

Chapter 5

Probing activation-driven changes in coagulation factor IX by mass spectrometry

Chapter 6

Summarizing discussion