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Chapters

2O21: A Vascular Odyssey

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Chapter 1

General introduction

Chapter 2

Endothelial specific GTPase signaling during leukocyte extravasation Rho GTPases.

Chapter 3

The role of the endothelium in the onset of antibody-mediated TRALI.

Chapter 4

Double hit-induced leukocyte extravasation is driven by endothelial adherens junction destabilization. Abstract

Chapter 5

ADAM10-Mediated Cleavage of ICAM-1 Is Involved in Neutrophil Transendothelial Migration. Abstract

Chapter 6

Endothelial Cells of Pulmonary Origin Display Unique Sensitivity to the Bacterial Endotoxin Lipopolysaccharide.

Chapter 7

A pulmonary endothelial amplification loop induced by both lipopolysaccharide and HLA class I antibody aggravates ex-vivo TRALI via increased TLR4 and ICAM-1 expression.

Chapter 8

General discussion and future perspectives