Chapters
Neutrophils, from Stem Cells to Immune SuppressorsDownload thesis (University repository, when available)
Chapter 1
General introduction and outline of this thesis
PART I – STEM CELL-DERIVED NEUTROPHILS TO MODEL HUMAN DISEASE
Chapter 2
Generation and characterization of patient-derived iPSC lines
2.1 Generation and characterization of a human iPSC line SANi006-A from a Gray Platelet Syndrome patient Abstract
2.2 Generation and characterization of a human iPSC line SANi007-A from a patient with a heterozygous dominant mutation in ELANE Abstract
2.3 Generation and characterization of a human iPSC line SANi008-A from a Chédiak-Higashi Syndrome patient Abstract
2.4 Generation and characterization of a control and patient-derived human iPSC line containing the Hermansky Pudlak type 2 associated heterozygous compound mutation in AP3B1 Abstract
Chapter 3
Efficient production of erythroid, megakaryoid and myeloid cells, using single cell-derived iPSC colony differentiation Abstract
Chapter 4
Induced pluripotent stem cell-derived neutrophils to model Hermansky Pudlak syndrome type 2
Chapter 5
Neutrophil specific granule deficiency and impaired NETosis in Gray Platelet Syndrome caused by NBEAL2 deficiency Abstract
PART II – NEUTROPHILS AS MYELOID-DERIVED SUPPRESSOR CELLS
Chapter 6
Activated neutrophils exert myeloid-derived suppressor cell activity damaging T cells beyond repair Abstract
Chapter 7
Neutrophils as suppressors of T cell proliferation: Does age matter? Abstract
Chapter 8
Different MDSC activity of G-CSF/Dexamethasone mobilized neutrophils: benefits to the patient? Abstract
Chapter 9
General Discussion
