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Chapters

The tango lesson: Complement and hemolysis in the pathogenesis of thrombosis in AIHA

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Introduction

General introduction and scope of the thesis Abstract

Chapter 1

α1-antichymotrypsin present in therapeutic C1-Inhibitor products competes with selectin-Sialyl LewisX interaction Abstract

Chapter 2

Complement C3 inhibition by compstatin Cp40 prevents intra- and extravascular hemolysis of red blood cells Abstract

Chapter 3

Iron-driven alterations on red blood cell-derived microvesicles amplify coagulation during hemolysis via the intrinsic tenase complex Abstract

Chapter 4

A novel rat model of complement-mediated intravascular hemolysis to study the pathogenesis of thrombosis in autoimmune hemolytic anemia

Chapter 5

Summary and future perspectives