Chapters
Novel insights into structure and function of Factor XIDownload thesis from university repository (when available)
Chapter 1
Genèral introduction and outline of thesis
Chapter 2
Hydrogen-deuterium exchange mass spectrometry highlights conformational changes induced by factor XI activation and binding of factor IX to factor Xla abstract
Chapter 3
Structures of Factor XI and Prekallikrein bound to domain 6 of High Molecular Weight Kininogen reveals alternate domain 6 conformations and exosites
Chapter 4
Nanobodies against factor XI apple 3 domain inhibit binding of factor IX and reveal a novel binding site for high molecular weight kininogen abstract
Chapter S
Generation and characterisation of nanobodies targeting FXI
Chapter 6
A FRET-based assay for the quantitation of the thrombin-factor XI interaction abstract
Chapter 7
Thrombin activation of the factor XI dimer is a multi-staged process for each subunit
Chapter 8
Genera! discussion
