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Chapters

The fast and the furious: disorders of neutrophil development and function

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Chapter 1

General introduction

Chapter 2

When actin is not actin'like it should: a new category of distinct primary immunodeficiency disorders abstract

Chapter 3

MKL1 deficiency results in a severe neutrophil motility defect due to impaired actin polymerization abstract

Chapter 4

Formation of neutrophil extracellular traps requires actin cytoskeleton rearrangements abstract

Chapter 5

Defective neutrophil development and specific granule deficiency caused by a homozygous splice site mutation in SMARCD2 abstract

Chapter 6

Loss-of-function mutations in CSF3R cause moderate neutropenia with fully mature neutrophils: two novel pedigrees abstract

Chapter 7

Lack of eosinophil extracellular trap formation due to failure of plasma membrane breakdown in the absence of elastase

Chapter 8

Neutrophil specific granule and NETosis defects in gray platelet syndrome abstract

Chapter 9

General discussion