Chapters

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Part one: Overview

General introduction and scope of the thesis

Chapter 1

Epidemiology and management of fetal and neonatal alloimmune thrombocytopenia
abstract

Part two: Natural history of HPA-1a mediated FNAIT

Chapter 2

HIP (HPA-screening in pregnancy) study: protocol of a nationwide, prospective and observational study to assess incidence and natural history of fetal/neonatal alloimmune thrombocytopenia and identifying pregnancies at risk
abstract

Chapter 3

Natural history of human platelet antigen (HPA)-1a alloimmunised pregnancies: prospective observational cohort study

Chapter 4

Placental complement activation in fetal and neonatal alloimmune thrombocytopenia: an observational study
abstract

Part three: Clinical relevance of HPA-5b antibodies

Chapter 5

Clinical characteristics of human platelet antigen (HPA)-1a and HPA-5b alloimmunised pregnancies and the association between platelet HPA-5b antibodies and symptomatic fetal neonatal alloimmune thrombocytopenia
abstract

Part four: Neonatal management

Chapter 6

Postnatal treatment for children with fetal and neonatal alloimmune thrombocytopenia: a multicentre, retrospective cohort study
abstract

Part five: Long-term outcome

Chapter 7

Children newly diagnosed with fetal and neonatal alloimmune thrombocytopenia: neurodevelopmental outcome at school age

Chapter 8

Long-term neurodevelopmental outcome in children after antenatal intravenous immune globulin treatment in fetal and neonatal alloimmune thrombocytopenia
abstract

Part six: Cost effectiveness

Chapter 9

Cost-utility analysis of screening of pregnant women for fetal neonatal alloimmune thrombocytopenia

Part seven: Summary and discussion

Chapter 10

General discussion and future perspectives