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Chapters

Shaping neutrophil responses against cancer: the role of integrin regulation

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Chapter 1

General introduction

PART I: lntegrin regulation in neutrophil host defense

Chapter 2

β2 integrin signaling cascade in neutrophils: more than a single function abstract

Chapter 3

SKAP2 acts downstream of CD11b/CD18 and regulates neutrophil effector function abstract

PART II: Neutrophil cytotoxicity towards tumor cells: unleashing the brakes

Chapter 4

KINDLIN3-dependent CD11b/CD18-integrin activation is required for potentiation of neutrophil cytotoxicity by CD47-SIRPα checkpoint disruption abstract

Chapter 5

The sialic acid-SIGLEC axis limits neutrophil ADCC against solid tumors through regulation of the CD11b/CD18 integrin affinity abstract

Chapter 6

Cancer cells resist antibody-mediated destruction by neutrophils through activation of the exocyst complex abstract

Chapter 7

General discussion