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Chapters

Liquid biopsies in pediatric rhabdomyosarcoma and beyond

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Chapter 1

lntroduction and outline of this thesis

Part 1: liquid biopsies in pediatric rhabdomyosarcoma

Chapter 2

Improving Risk Stratification for Pediatric Patients with Rhabdomyosarcoma by Molecular Detection of Disseminated Disease abstract

Chapter 3

Novel Circulating Hypermethylated RASSF1A ddPCR lor liquid Biopsies in Patients With Pediatric Solid Tumors abstract

Chapter 4

Cell-free DNA as a diagnostic and prognostic biomarker in pediatric rhabdomyosarcoma abstract

Chapter 5

Molecular Characterization of Circulating Tumor DNA in Pediatric Rhabdomyosarcoma: A Feasibility Study abstract

Chapter 6

Targeted Locus Amplification to develop robust patientspecific assays for liquid biopsies In pediatric solid tumors abstract

Part Il: Extracellular vesicles and cell-free RNA

Chapter 7

Extracellular Vesicles: A New Source of Biomarkers in Pediatric Solid Tumors? A Systematic Review abstract

Chapter 8

Cell-free RNA from plasma in patients with neuroblastoma: exploring the technical and clinical potential abstract

Chapter 9

Discussion and future directions