Chapters

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Chapter 1

General introduction

Part I: structure and function of (IgM) antibodies

Chapter 2

At critically low antigen densities, IgM hexamers outcompete both IgM pentamers and IgG1 for human complement deposition and complement-dependent cytotoxicity abstract

Chapter 3

CD5L is a canonical component of circulatory IgM abstract

Chapter 4

Characterization of monoclonal IgM in Waldenström Macroglobulinemia

Chapter 5

Factors affecting IgG4-mediated  complement activation abstract

Part II: Rheumatoid factor responses in health and autoimmune disease

Chapter 6

Identification of clinically and pathophysiologically relevant rheumatoid factor epitopes by engineered IgG targets abstract

Chapter 7

Rheumatoid Factor repertoire profiling reveals distinct binding epitopes in health and autoimmunity abstract

Chapter 8

Longitudinal rheumatoid factor autoantibody responses after SARS-CoV-2 vaccination or infection

Chapter 9

Different rheumatoid factor binding patterns distinguish between primary and RA-associated Sjögren’s Disease

Chapter 10

Next-generation rheumatoid factor assay provides improved predictive power for the development of arthritis in patients at risk

Chapter 11

General discussion