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Chapters

Risks and potential benefits of adoptively transferred virus-specific T cells

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Chapter 1

General introduction and aims of the thesis

Chapter 2

Trackingthe progeny of adoptively transferred virus-specific T cel Is in patients posttransplant using TCR sequencing abstract

Chapter 3

Magnitude of off-target allo-HLA reactivity by third-party donor-derived virus-specific T cells is dictated by HLA- restriction abstract

Chapter 4

Public T-cell receptors (TCRs) revisited by analysis of the magnitude of identical and highly-similar TCRs in virus- specific T-cell repertoires of healthy individuals abstract

Chapter 5

Identification of functional HLA-A*01:01-restricted Epstein-Barr Latent Membrane Protein 2—specific T-cell receptors abstract

Chapter 6

Amino acids at position 5 in the peptide/MHC binding region of a public virus-specific TCR are completely inter- changeable without loss of function abstract

Chapter 7

Summary and general discussion