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As a result of one donation, whole blood donors lose approximately 200-250 mg of iron. Depending on the decrease in ferritin levels after a whole blood donation and the rate of restoring iron to pre-donation levels, optimal donation intervals may differ between donors.

Ferritin levels of 300 new whole blood donors were measured from stored (lookback) samples from each donation over a two-year period.  Ferritin trajectories were then plotted and grouped in order to identify subgroups of donors with differing trajectories to tailor donation intervals to. Publications are found here.