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Chapters

Effect of red cell transfusion on the host immune response in critically ill patients'

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Chapter 1

General introduction and outline of this thesis

Chapter 2

The ability of extracellular vesicles to induce a pro- inflammatory host response.  Abstract

Chapter 3

Pathogenesis of non-antibody mediated transfusion- related acute lung injury from bench to bedside. Abstract

Chapter 4

Monocyte mediated activation of endothelial cells occurs only after binding to extracellular vesicles from red blood cell products, a process mediated by beta integrin. Abstract

Chapter 5

The effect of red blood cell transfusion on iron metabolism in critically ill patients.  Abstract

Chapter 6

Red blood cell transfusion results in adhesion of neutrophils in human endotoxemia and in critically ill patients with sepsis. Abstract

Chapter 7

The effect of red blood cell transfusion on platelet function in critically ill patients.  Abstract

Chapter 8

Transfusion of 35 days stored red blood cells does not alter lipopolysaccharide tolerance during human endotoxemia. Abstract

Chapter 9

Summary and discussion of this thesis