Chapters
In vitro blood production from induced pluripotent stem cellsDownload thesis (when available at university repository)
Introduction
1.1 General introduction
1.2 Erythropoiesis and Megakaryopoiesis in a Dish
Results
2.1 Generation of multiple iPSC lines
Generation and characterization of human iPSC line MML-6838-Cl2 from mobilized peripheral blood derived megakaryoblasts Abstract
Generation and characterization of human iPSC lines SANi001-A and SANi002-A from mobilized peripheral blood derived megakaryoblasts Abstract
Generation and characterization of a human iPSC line SANi005-A containing the gray platelet associated in GFI1B.heterozygous mutation p.Q287* Abstract
Generation of human erythroblast-derived iPSC line using episomal reprogramming system Abstract
2.2 Efficient production of erythroid, megakaryocytic and myeloid cells, using single cell-derived iPSC colony differentiation.
2.3 Human induced pluripotent stem cell-derived blood products: state of the art and future directions.
2.4 LSD1/KDM1A and GFI1B orchestrate hematopoietic emergence from induced pluripotent stem cells.
2.5 Molecular mechanisms of bleeding disorder-associated GFI1B Q287* mutation and its affected pathways in megakaryocytes and platelets.
2.6 The RNA-Binding Protein ATXN2 is Expressed during Megakaryopoiesis and May Control Timing of Gene Expression.
Discussion
3.1 General discussion
Appendix
4.1 Een decennium geïnduceerde pluripotente stamcellen; een overzicht.
4.2 Summary/samenvatting
