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Chapters

Rheumatoid Factors

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Chapter 1 

General introduction.

Chapter 2

Evolution of autoantibody responses in individuals at risk of rheumatoid arthritis. Abstract

Chapter 3

Clinically relevant discrepancies between different rheumatoid factor assays. Abstract

Chapter 4

IgG subclass specificity discriminates restricted IgM rheumatoid factor responses from more mature anti-citrullinated protein antibody-associated or isotype-switched IgA responses. Abstract

Chapter 5

Engineered IgG-targets identify clinically and pathophysiologically relevant rheumatoid factor epitopes. 

Chapter 6

Rheumatoid factors do not preferentially bind to ACPA-IgG or IgG with altered galactosylation. Abstract

Chapter 7

Anti-hinge antibodies recognize IgG subclass- and protease-restricted neoepitopes. Abstract

Chapter 8

On the origin of rheumatoid factors: Insights from analyses of variable region sequences. Abstract

Chapter 9

General discussion.